Does Shadow the Hedgehog trust humans?

Answer 1

Not necessarily, as Shadow has been mistreated by humanity numerous times. The most recent time being when it was discovered in Sonic 06, that the government sealed Shadow in the future. Due to the events being erased, whether this still occurs is unknown.

Answer 2

Not really, he has reasons behind this though.

50 years ago, Maria, his best friend, was killed in front of him by a Government soldier.

And in the events of Sonic 06, humanity is said to have gone against Shadow out of fear of his power, and sealed him in a pink cage like object.