Depends on the individual. Some people use runes for divination. Others use them for protective magic.
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No staff will really MAKE runes; however, some staffs will SAVE you the runes when you use the corresponding spell. Thus, by wielding a staff of fire, or one of the more advanced versions, you will need no fire runes for any spell (for instance, combat spell, or high alchemy) that normally requires them.
The spell Ice Blitz requires three Water Runes, two Blood Runes, and two Death Runes.
Because you touch yourself at night...
crafting runes at alters. Use runes ess at certain alter to craft those runes. Eg water alter you crft water runes.
Runes of magic is a game that is based in a magic medieval world.