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yes you can but you have to talk to the king in lummy castle 1st then go to wizards castle (use your map to find) and give the talisman to the wizard whom the king told you to go to. Then the wizard will give you instructions on how to make a talisman.

The above answer is incorrect. It was directed at the "Rune Mysteries" quest. You can't make your own Talismans. There may be certain NPC's that can help you get them such as some in the Rc'ing guild. But no, you cannot make your own.

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Q: Can you make a talisman in runescape?
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