no.
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Yes. Obelisk is only protected from cards that target him. Dark Hole does not target any of the monsters it destroys, even if there is only one. So it will destroy Obelisk.
Normal summon, no. Special summon, yes.The reason is, when Obelisk is normal summoned, no spells, traps or monster effects can be activated. That means it prevents anything being activated in the 'summon response' window, which is where you'd normally use cards like Trap Hole, Bottomless Trap Hole, Torrential Tribute, etc.
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Yes. Because Obelisk the Tormentor is only protected from card effects that do not target, Tribe-Infecting Virus will be able to destroy Obelisk the Tormentor via its effect.
A card's continuous effect will be applied before players can activate cards like Trap Hole. That means potentially Muka Muka will be summoned with a high enough ATK to allow a player to use Trap Hole to destroy it.