The volume of the 220mg depends on what substance you are measuring and knowing the density of that substance. There are 5cc per teaspoon.
The easy calculation is for water which has a density of 1 gram/cc. In the case of water, 220 mg would be approximately 0.04 teaspoons.
Here's another example. If you were to measure lead which has a density of 11.35 g/cc, then 220 mg would be approximately 0.004 teaspoons.
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