The 39 clues is about these two kids named Amy and Dan Cahill. When their grandmother passes away she gives her relatives a choice: 1 million dollars or the start to the hunt for the 39 clues. Amy and dan chose the hunt and travel around the world for clues. Their au pair, Nellie Gomez, goes with them on the hunt so that the two minors would not get caught, since they are two minors traveling aound the world.
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In the fourth book Beyond the Grave, by Jude Watson, Amy, Dan and Nellie go to Egypt. Amy, still recuperating from their latest betrayal, gets a clues from a Sakhet statue, once owned by their grandmother, Grace. They are taken in by a friend of Grace, but then they are betrayed once again...
In this book, In Too Deep, by Jude Watson, the clue hunt takes Amy, Dan and Nellie to Australia, following the footsteps of the notorious "Bob Troppo" along with their cousin, Shep. In the end of the book, there is a great fire, and a person once thought as an enemy sacrifices their life for Amy, Dan and Alistar Oh.
It's pretty simple. In the first book it said you will be the mst powerful person on Earth. The real prize is the master serum that Gideon Cahill created. Each of his children got 1/4 of the serum. Luke, founder of the Lucians, got the 1 that enhanced skill and stealth. Kathrine, founder of the Ekaterinas got the 1 that enhanced the mind. Thomas, founder of the Tomas got the 1 that enhanced strength. And Jane, founder of the Janus, got the 1 that enhanced artisticness.
But Madeline, the 5th child (born after Gideon died in the fire) founded the Madrigals and didn't get part of the serum but the Madrigals' mission is to keep balence and peace. Spoiler alert: Dan and Amy are Madrigals but seemed they were Ekats before the 7th book.
Gideon took the master serum and faced Damien Wesper. Gideon was skilled, smart, strong, and artistic (the master serum gives all 4 abillities). The side effect is Gideon got very weak. When Vesper tried to take the serum Gideon told his familly to run and he blew up his lab. The 3 other children thought Luke started the fire and turned on him but when he left Jane (the youngest) followed him. But in book 11 it never mentions where she went 'cause she's not with luke.
The treasure of the 39 Clues is the source of the Cahill family's power and wealth, rumored to be the key to ultimate power. Each book in the series reveals a different clue that leads to the treasure's location.