Irene is an in-Valid because she has a heart problem. People with conditions can't be risked into space because accidents may occur.
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He has an extra finger on each hand allowing him to play peices musicians with ten fingers cannot.
Vincent is considered an in-valid. Jerome is a valid. Vincent needed Jerome's genes to work at Gattaca.
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Vincent Freeman is conceived and born without the aid of this technology. Most of the babies in GATTACA were test tube babies. Vincent was a in-valid because of this.
The four "bases" in DNA are G, A, T, and C So it's a word made up from those four letters.