She left because Alyssa Milano and Shannen Doherty got into fight. Alyssa Milano and Holly Marie Combs were on a contract and could not go so they stayed.
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"Charmed" is no longer in production. Prue did not return as at the series finale.
He left because he didn't get along with Shannen Doherty (Prue).
The first main character to die in Charmed was Andy (Prue's boyfriend). But out of the sisters Prue was the first to die
Shannen Doherty
Shannen Doherty played Prue Halliwell in Charmed.