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She is his sister.Not ONLY is she his sister. He likes her energy on camera.
Joan Cusack
They are real life brother and sister.
Joan Ciccone's birth name is Joan Gustafson.
John Cusack and Joan Cusack are brother and sister. He also has three other siblings, Ann Cusack, Bill Cusack and Susie Cusack, who are also in show business. Joan is older than John by about 3 years.