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Although the great dane is a large powerful dog, the puma weighs as much, and no dog alive can win in a real battle with a big cat that really wants to kill the dog. I found several records of pumas killing hounds, hounds used for puma tracking, so your dane would not have a chance against the puma at all. I found where a leopard killed two rottweilers in India, and the leopard and puma are close in size and strength.
This answer is not accurate. There are many documented cases of Danes and Dogo Argentinos killing large cats. Morocho the Dogo killed a puma while protecting his family and lived (see the story on YouTube, simply look up: Dogo Argentino "Morocho" saves 2 girls from Puma attack The Dogo is bred with at least 30 percent Great Dane in their genetic makeup. Great Danes have killed many wild predators, to include tigers. Sometimes dying in the process.
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