Glenn Close
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He first met his mother, Mona Simpson (voiced by Glenn Close) in "Mother Simpson", season 7, episode 8 which aired in 1995.
Mona was 76 & Abe's last stated age is 83
Herbert Powell ("Uncie Herb" to Bart & Lisa) was voiced by Danny Devito
Homer's mothers name is Mona Simpsons. We first learn this in the episode "O' Brother Where Art Thou". Homer also learns he has a Half-Brother in this same episode.
She's in at least 2 that I"ve seen.