A hell hound rips at her stomach and she risks her life to help sam and dean escape by blowing herself up
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I'd have to assume you're talking about Supernatural. If so then Jo dies in season 5 episode 10, Abandon All Hope. In this episode she, Jo, sacrifices herself for Sam and Dean.
Jo dies in season 5 episode 10 titled Abandon all Hope
Bobby Jo Moore has: Played Gloria in "Level 9" in 2000. Played Mona in "The Chris Isaak Show" in 2001. Played Hooker in "Just Cause" in 2001. Played Allisa - The Tower Base in "Tilt" in 2003. Played Actress in "The Long Weekend" in 2005. Played Girl in Towel in "Bad Girls from Valley High" in 2005.
Betty Jo Bradley was played by Linda Kaye . The role of Bobbie Jo Bradley was played by both Pat Woodell and Lori Saunders . Billie Jo Bradley had been played by Jeannine Riley , Gunilla Hutton and Meredith MacRae .
In the show Beetleborgs, Jo was originally played by Shannon Chandler, when she left the series and her character remained, Jo was played by Brittany Konarzewski. Halfway through season one Wolfgang was playing with a magic book and accidentally cast a spell on Jo that changed her appearance.