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Joe was saving some Christmas presents from being stolen by the Grinch on top of a roof, and as he was walking away with the gifts the Grinch threw a roller-skate underneath Joe's foot. He then slipped on it and fell off the roof, breaking his legs.
So to answer your question, it was The Grinch, Joe was fighting before he was paralyzed.
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Earn +20 ptsQ: Who did Joe from Family Guy fight before he was paralyzed?
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