The very beginning of season 5, right after he marries Emily.
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The episode in which Diane left Cheers was "I Do, Adieu." it was the fifth season finale episode and it aired on May 7, 1987. Diane left to hone her writing talents.
If your talking about the Manga, chapter 181, (The Battle Begins) For Anime episode 109 an (invitation from the sound). this episode is the saddest episode for me.
I think he saved her on Pokemon movie rise of darkai or arceus jewel of life
Yes. In The Vegas Episode He Gets Married To Jim's Sister..She Leaves Him The Next Day
Satie, Erik: Gymnopédies No. 1 piano