It's not been revealed what his biggest fear is- some have suggested that it is the annihilation of the Universe, others that it is the loss of the TARDIS. We can only guess at what his biggest fear is, taking hints from different episodes over the past 5 decades.
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Harry Styles' biggest fear is rollercoasters.
Katie Puryear's biggest fear is spiders.
a heartbreak
Charlie sheen
a guy whos human whos not a wrestler