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The Ames test is one of the oldest, most common tests for mutagens. It uses a strain of S. typhimurium that contains a mutation which prevents the synthesis of histidine, an essential amino acid.

The test measures the rate of reversion mutation; ie., the bacteria must regain the the ability to synthesize histidine to grow. Chemicals which increase the rate of mutation increase the number of colonies which grow on minimal media. Here we will be testing the ability of several substances to cause reversions.

The use and advantages of the Ames test is based on the assumption that any substance that is mutagenic may also turn out to be a carcinogen, that is, to cause cancer. Although, in fact, some substances that cause cancer in laboratory animals do not give a positive Ames test (and vice-versa), the ease and low cost of the test make it invaluable for screening substances in our environment for possible carcinogenicity.

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14y ago
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13y ago

All microbio lab books says is that not all mutagens used are carcinogens. Time can also play a role, you have to run a whole lot of tests

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Related questions

What is the purpose of the ames test?

The Ames test identifies chemical mutagens.


Can you reduce animal killing using AMES test?

not with ames but with animes


Are substances that test positive with the Ames test necessarily carciongenic in humans?

The substances that are test positive with Ames test may or may not be carcinogenic for humans. Similarly, some substances that cause cancer in laboratory animals do not give a positive result Ames test. It is not possible to decide the carcinogenicity of any substances only depending on the Ames test.


In what field of science would one carry out an Ames test?

Ames test would typically be carried out in the field of biology, more specifically toxicology. The Ames test involves testing genetics, which involves taking a sample and examining it closely in a laboratory.


What is the test used for detecting chemicals with carcinogenic potential?

The Ames Test


Purpose of liver extract in the Ames test?

Ames test is used to test whether a certain substance is mutagenic. Liver extract is optionally added to simulate the effect of metabolism, as some compounds, like benzo[a]pyrene, are not mutagenic themselves but their metabolic products are.


What is advantages and disadvantages of weekly test?

what is the advantages of weekly test


Is mike Holmes in a relationship with corin ames?

No, He has three children, and is married.


Describe the control component in an Ames Test?

The control component in an Ames Test typically includes a negative control (no chemical exposure) to ensure background levels of spontaneous mutations, and a positive control (known mutagen) to validate the sensitivity of the assay. These controls help researchers interpret the results of the test by providing a baseline for comparison.


When did Blanche Ames Ames die?

Blanche Ames Ames died in 1969.


When was Blanche Ames Ames born?

Blanche Ames Ames was born in 1878.


What is national advantages?

test