Okami
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Check out the anime movie "Wolf Children" its got a wolf girl and a boy, I recommend it.
Among some of the more serious anime series you will find Ghost in the Shell (films and series) , Ergo Proxy , Tehxnolyze , Serial Experiments Lain , Cowboy BeBop , Wolf's Rain and others .
If your talking about the animated wolf movie, the names of the main characters are Kate and Humphrey. Other characters are Lilly Garth Paddy Marcel Winston Tony Can-Do Hutch Eve and more.
Aleu, Kodi, Dingo, Saba and two others they are unnamed
Some Anime and Manga like Ah My Goddess:Onegai teacher - Alien milfLove Hina - Guy is in charge of a girl's dormChobits - Guy and his scientifically advanced blow up doll (joke)Sekirei - Magical milfSpice & Wolf - Fox milfDearS - Magical milf (now with blue hair)Okusama wa Mahou Shoujo - Magical milf.Queens blade-Fighting(Clothing rips alot)