It depends on how you're defining "mean".
"Airport '07" has a man beating his wife.
"I Am Peter Hear Me Roar" has some derogatory remarks about women.
"Baby Not On Board" has Aquaman preventing a woman from being attacked.
There's more but that's all I can think off off hand.
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No.
Family Guy Petoria Episode.
The 255th episode aired on Family Guy was "Peter's Sister"
It is an episode of Family Guy
Season 7, Episode 1