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Hmm... how should I answer this question? Simply put, Orochimaru was not killed by Itachi, but by Sasuke. Sasuke killed Orochimaru in Orochimaru's weakest condition, knowing that Orochimaru had no more power to grant him.
no, it's the other way around no, it's the other way around
Orochimaru isn't killed by Sasuke, he is just sealed inside Sasuke's body. When Shikamaru and Naruto kill Kakuzu and Hidan, Sasuke learns last technique from Orochimaru and realizes that Orochimaru is weaker than himself. During the battle between Sasuke and Itatchi, Itatchi draws Orochimaru out of Sasuke and kills him.
he didn't Sasuke killed Orochimaru himself ,well sort of.
Yes, Orochimaru does die. When Orochimaru tries to hold Sasuke in one place so Orochimaru can inhabit Sasuke's body and control the Sharingan he possesses, Sasuke uses the Sharingan against him and kills Orochimaru, all before his assistant comes back after he left to take care of some business.