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Yes and no. It's based off of the Gloucester High School teen pregnancy controversy where 18 students got pregnant in 2008. The principal said that there was a pact for all these students to become pregnant at once but one of the pregnant students came out and said that there was no such pact.

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No, Knocked Up (2007) is not based on a true story. There have certainly been countless couples who have accidentally gotten pregnant, but the movie is not based on any real life couple's story in particular.

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Q: Is the movie the pregnancy pact based on a true story?
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