Yes.
In a 2004 interview with Natalie Portman, Dwayne Michael Carter, Jr., known by his stage name "Lil Wayne" confided that "when [he] was growing up, [his] friends would tease him about his [small genitalia], and would call him 'Lil Wayne'." He has adopted the name as a way of proving to those who would tease him that he can rise above the mockery.
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