No, these two actors are not related.
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Yes, married to Nick Clooney, mother of George Clooney
Nina Bruce-Warren Clooney (born April 7, 1939)
George Clooney
George Clooney
Actor George Clooney does not have any children. As of September 2014, Hollywood's favorite bachelor has finally settled down and gotten married to human rights lawyer Amal Alamuddin. The couple currently have no children together.