Did Lois ever have an affair with quagmire?

Answer 1

I think after that episode of Family Guy buisness guy, peter gets amneisa and Lois tries to help him remember who he is, but when Lois see him flirting with a another woman she takes of with the kids. and this is quagmire's time to be with Lois

Answer 2

on meet the quagmires in season 5 episode 18. and after business guy

is Big man on hipppcampus is about when peter hits his head and suffers amnesia

he forgets everything about his life including his family and friends, in an attempt to

try to bring back his memory Lois decides to reintroduce peter to his old self . until he begins to hit on other woman.

much to Lois's dismay she decides to take the kids and leave peter, giving quagmire the opportunity to score with Lois , peter now must prove to Lois he can remember her and make himself worthy of her again. Oh yeah when I mean business guy it's season 8 episode 19 and were talking about family guy

Answer 3

Yes, she spent one night with Bill Clinton.