I was curious about this because I saw her in the 1957 movie "Desk Set".
She was born in 1907, so she was age 50 when this was filmed. I thought she had a "smokers face", though I don't think she appeared smoking in any film I had seen; e.g., African Queen.
So I researched this- she was indeed a smoker, though she may have quit before her death at age 96.
There is at least 1 photo on the internet of her holding a cigarette, not from a film.
Towards the end of her life it is mentioned that she was in failing health, though I saw no details available about that.
After many years of smoking, it is well accepted that this has a very detrimental effect on a person's appearance, especially in the face.
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YES
Spencer Tracy Katharine Hepburn and Spencer Tracy appeared in nine films together.
Joshua Jackson is a smoker. Some other celebrities that smoke include Katherine Heigl, Britney Spears, as well as Jessica Alba.
Katharine Hepburn went by First Lady of Cinema, Kate, and The Great Kate.
No, Audrey Hepburn is not single.