=Holly and Shannen were best friends before the show and have still stayed friends now.==Holly and Alyssa are also best friends.==However Alyssa and Shannen fell out frequently and didn't stay friends.==Alyssa Milano and Brian Krause Dated.==As did Shannen Doherty and Julian McMahon.=
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Holly Marie Combs of charmed season episodes has featured in "Mistress" as Jane
they dated in 2003. unfortunately mischa became more selfish and ended the relationship in mid-2004. mischa is no longer friends with any of the other cast members of the OC. sadly.
Most have gone on with their families. I know Alyssa is welcoming a baby boy with her husband sometime within the next couple of months.
I don't know about the others but Holly Marie Combs (Piper) is playing Aria's mother in the ABCFamily series Pretty Little Liars
The cast was on Larry King, I think in 2007, except for Laurie Metcalf. When Larry King asked about her Roseanne was very abrupt and said rather nastily "Who cares".