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No. A lot of entertainers have same last name, but no relation.
Rosie O'Donnell is the daughter of Roseann Teresa, a homemaker, and Edward Joseph O'Donnell, an electrical engineer who worked in the defense industry. O'Donnell, the third of five children, was born March 21, 1962 in Bayside, Queens, New York and raised in Commack, New York.
Chris O'Donnell, the youngest of seven children (with four sisters and two brothers), was born June 25, 1970 in Winnetka, Illinois, the son of Julie and William O'Donnell, Sr., a radio manager. O'Donnell is of paternal Irish American and maternal German descent.
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