to some extent it comes down to how much you eat and how regularly you eat it. eating lots of vitamin b and exrcising lots can improve your metabolism.
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DNA is the genetic code
for the genetic engenerring to take place it needs genetic code like for a car to drive you need to put gas in it. its simple
genetic modification can be bad because animals and stuff are changed to taste better but im not sure if that is genetic engineering
Short Answer is: our understanding of genetic engineering.
I don't think inflammation is genetic.