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Depending on what you are referring to with the term Lycan, there are many things which can kill them.

In terms of the Underworld Series, silver severely weakens a lycan, and a heavy amount can kill. If can also kill them if silver is introduced directly into the bloodstream, causing a mass and instant effect.

Other "common" methods can also kill a lycan, such as severely damaging the body, severing the brain stem from the rest of the body (breaking its neck), and shooting them in the head. Basically any common method which would cause mass or severe damage would kill a lycan, as although they may be immortal or have a high tolerance and heal rate, they are still as vulnerable as humans.

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Q: How do you kill a Lycan?
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