No, but Scarlet Witch has fought against a giant before and shrunk him down in size to the point where he is much smaller than her and tiny in size compared to her, making her look like the giant instead. She then grab him, taking advantage of his tiny size and flicked him so hard that he got knocked out
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A friend once told me that she grew when she held the serpent crown, but I haven't been able to find any other mention of it.
In the comics, Scarlet Witch has not been depicted as becoming a giantess. Her powers generally revolve around reality manipulation, chaos magic, and hexes rather than changing her physical size.