Use up would be an antonym for replenish.
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The antonym for replenish is deplete. This means to reduce or exhaust resources rather than restore or fill them.
The opposite of replenish is deplete.
After a long day of hiking, I stopped at the store to replenish my water supply.
After a long hike, it's important to replenish your energy by drinking lots of water and eating a nutritious snack.
One antonym of ozone is pollution.
The antonym of stable is unstable.