Take U.S. 1 SOUTH from Presque Isle to I-95 in Houlton; follow signs to I-95 SOUTH to BANGOR.
Take I-95 SOUTH all the way down to Florida STATE ROAD 70 - OKEECHOBEE RD at EXIT 129 in FLORIDA; turn right off the exit ramp onto SR-70 OKEECHOBEE RD - WEST. To bypass RICHMOND & PETERSBURG, take I-295 SOUTH (EXIT 84A off I-95 in Virginia).
Take SR-70 WEST on Okeechobee Rd briefly to FLORIDA'S TURNPIKE (toll); turn left onto FLORIDA'S TURNPIKE (toll), then stay right past the toll booth to go onto the TURNPIKE (toll) SOUTH to MIAMI.
Take the TURNPIKE (toll) SOUTH to U.S. 1 at END Florida's Turnpike in HOMESTEAD.