In general it is the valve lifters if it has higher mileage. Is the sound comming from the valve cover (usually it is the part of the motor that has the manufacturer name on it). It also could be much worse, if you are not sure take it to an auto tech. Another item to check: Could be the grade (or brand) of fuel being used. Too low of an octane rating will produce a "knocking" sound when accelerating ... the burn temperature of the lower grade fuels is much higher than, say, 91 octane which ignites at a lower temperature.
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