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Graded potentials are generated by ligand-gated channels and mechanically-gated channels. Ligand-gated channels open in response to chemical signals, while mechanically-gated channels open in response to physical stimuli such as pressure or touch. Both types of channels allow ions to flow across the membrane, leading to changes in membrane potential.
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There are voltage-gated ion channels and ligand-gated ion channels, and since both are stimuli the term stimulus-gated is a redundancy.
ligand-gated or voltage-gated ion channels.
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Ionotropic receptors are ligand-gated or transmitter gated ion channels. The binding of a neurotransmitter or other ligand to a particular site on a domain of a protein in the receptor causes a conformational change in the protein subunits. This allows a certain ion to pass through, poteitally potassium, sodium or chloride. There are two types of ionotropic receptors, non-NMDA and NMDA. Both are ligand gated receptors, however the NMDA is also voltage gated.
Change in the voltage across the membrane, ligand binding, and mechanical stress.
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1921