Graded potentials are generated by ligand-gated channels and mechanically-gated channels. Ligand-gated channels open in response to chemical signals, while mechanically-gated channels open in response to physical stimuli such as pressure or touch. Both types of channels allow ions to flow across the membrane, leading to changes in membrane potential.
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There are voltage-gated ion channels and ligand-gated ion channels, and since both are stimuli the term stimulus-gated is a redundancy.
ligand-gated or voltage-gated ion channels.
Voltage-gated channels are activated by changes in membrane potential, while ligand-gated channels are activated by binding of specific molecules (ligands). Voltage-gated channels open in response to changes in electrical charge across the membrane, allowing ions to flow through. Ligand-gated channels open when a specific molecule binds to them, triggering ion flow. Both types of channels play important roles in regulating the flow of ions in and out of cells, but they are activated by different mechanisms.
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Ionotropic receptors are ligand-gated or transmitter gated ion channels. The binding of a neurotransmitter or other ligand to a particular site on a domain of a protein in the receptor causes a conformational change in the protein subunits. This allows a certain ion to pass through, poteitally potassium, sodium or chloride. There are two types of ionotropic receptors, non-NMDA and NMDA. Both are ligand gated receptors, however the NMDA is also voltage gated.
Change in the voltage across the membrane, ligand binding, and mechanical stress.
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