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Depends on how the fuse was blown in the first place. Maybe a short? But usually, no. Unless it is the main battery fuse, 80 AMP or higher, I wouldn't worry about it. If the fuse is screwed down, I would remove the batter cables just to be sure you do not accidentially arc a screwdriver. But otherwise, if it is a smiple 20 Amp fuse in the fuse block, go ahead and change it without removing the battery cable. If it blows as soon as you insert a new fuse, or activate what it was you were using, I.e. cigarette lighter, figure out what is causing the fuse to blow. Just make sure the key is off is the safe bet. Under no circumstances should you ever use a higher rated fuse than called for. It has the potential to melt wires and start a fire. I.e. Don't use a 30 Amp fuse in place of a 7 Amp if the 7 Amp keeps blowing.

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Q: Replace a car fuse do you disconnect the power?
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