Chevy s-10 truck one cylinder misfire?

Updated: 4/28/2022
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Need to know what year and what engine to help you.

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Q: Chevy s-10 truck one cylinder misfire?
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It means that more than one cylinder has a misfire history. PO301 would be cylinder number 1 misfire. PO302 would be number 3 cylinder misfire.

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Can a misfire make a truck not start?

You have not given enough information to even begin to answer this question. If the truck won't start, What makes you think that it has a misfire? A misfire is typically one or more cylinders not firing when the truck is running. If you indeed have a dead cylinder, that alone will not keep the engine from starting , unless you have catastrophic failure,(Something broken inside the given cylinder). However if you are not getting any fire then the truck will not start. Also if the truck has recently run & it ran rough, (As in mis-firing), then it may need a tune-up , (Or something more involved), & if that condition is bad enough; then YES, it could keep the engine from starting.

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