Niobe insulted their mother, Leto in saying during one of Leto's festivals that she was as worthy of worship as Leto for being mother to seven sons and seven daughters while Leto had only one son and one daughter; in punishment for this boast, Leto had her children kill all of Niobe's (or all but one daughter and one son).
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Her brother Apollo was angered by their friendship. Apollo challenged Artemis to an archery competition. He told her to shoot a target from far away. Artemis had no idea that the target her brother mentioned was the head of Orion. Artemis' shot was perfect (like always) so Orion died. Another version on how Orion died was that Apollo sent a scorpion to sting Orion in his heal. Gaea, Mother Earth, could of sent the scorpion instead of Apollo because she was upset that Orion was killing all of the wild beasts that lived on her. Yet another version on how Orion died: Orion tried to rape Artemis or one of her virgin followers. Being a virgin goddess, she killed him before he could.
Apollo and his twin sister Diana did not attack Niobe. They did however attack and kill Niobe's children because she had said to Leto, the mother of Apollo and Diana, that she (Niobe) was more of a mother who had 14 children than Leto who had only two.
Minerva or Athena, Artemis, Venus, Echo, and the Mother of Hercules. The mother of Hercules was an enemy because Zeus was fooling around with her and Hera got mad. So, she killed her and tryed to kill Hercules to .
Apollo, in some myths, was said to have killed Orion, Artemis' companion, by sending a giant scorpion to sting him. It is debatable that Artemis even loved Orion. In many other myths, it is Artemis that killed Orion.
There is no known myth about Artemis killing a cyclops.