Appears to be safe, although not enough research has been done. Mild side effects include bloating and nausea. Allergic reaction: chest pain, hives, rash, difficulty breathing, and itchy skin. And more . . .
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Recommended doses not associated with any significant side effects.
When taken in recommended doses there are no known side effects.
Cotton root bark has not been identified as producing side effects.
In rare cases the herb can cause nausea and stomach upset. No other side effects reported.
No side effects are known with proper application of the herb externally. Internal use of herbal preparations should be avoided pending further research.