You do not have to use primer when applying acrylic nails. However, it would be wise so as to protect your nails from the acrylics' adhesive. This can be as easy as applying a clear coat of polish before applying your acrylics.
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It's primer made with a latex or acrylic base. You can use any kind of paint over this.
You do NOT use regular paint as primer. It contains none of the qualities of primer.
If the primer and paint are the samebrand, and are recommended to be used together. yes. no problems will occur. primer coats are generally thinner (lower viscosity) and simply are used to provide adhesion to top coats, so unless you are simply using the primer as an expander, i dont see the point.... but yes is the answer
It's not hard to use; oil flows out better and gives you more work time than an acrylic primer. It does however, require mineral spirits for cleanup and take longer to dry.
If you are painting lettering directly to the plastic, there are single part epoxies that are available, some suitable for outdoor use, that would adhere to plastic without having to use a primer. If you are going to paint the background a solid color, you can use a special primer, formulated to adhere to plastic, then paint it with an acrylic paint which can then be coated with the same type of acrylic paint for any lettering and design.