Assuming you're talking about wood finishing, spar urethane can be used over a water sealer. In fact, the combination is better than just a sealant or just the spar urethane. A very durable finish for outdoor wood products is soaking the unfinished wood with boiled linseed oil, letting the linseed oil cure, removing excess cured linseed oil, then applying spar urethane.
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Yes, you can.
Why would you?
Look at label on can if urethane is oil based it should be fine. Think of it like basic chemistry. Oil and water dont mix, xlene based products are used to strip oil, so if ur using a xlene base over oil thats a no brainer. The urethane I use is a xlene base so I wld never use over oil. Im just not sure if they sell a oilbased urethane so check the labels
It's a very good marine quality varnish.
Yes, I just did it last week. If it's for outdoors, make sure to put 2 to 3 coats of poly on it. I recommend Minwax Helsman Spar Urethane.