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I assume you are asking about the mound builders. The huge answer to this is no immunity to European diseases. I will be back on this one.

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15y ago
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6mo ago

The Mississippians were a mound-building Native American culture that declined around 1450 due to a combination of environmental factors, social disruptions, and possibly conflict with other groups. This decline led to the dispersal of Mississippians into other cultures and the abandonment of their large ceremonial centers.

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Q: What happened to the Mississippians?
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