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Why a mutation which changes at least one amino acid in a protein sequence results in a change in shape of the protein formed?
Wiki User
∙ 12y ago
each amino acid helps build the new strand of DNA. Messenger RNA splits and replicates a strand of DNA. Therefore, if there is a mutation in the amino acid, the DNA cannot be replicated exactly. This could change the function of the protein for good, for worse, or there could be no change at all.
This is a little backwards, but the essentials are there. There is not a mutation in the amino acid; they are what they are and don't change their chemical identity. The mutation can occur in the DNA molecule itself or in RNA, which either transcribes (mRNA) or translates(tRNA) the DNA code incorrectly. In either case, if the DNA is either coded incorrectly on the chromosome or if its code is read incorrectly by either RNA molecule, the code will end up scrambled and the wrong amino acid will be brought to the developing protein molecule and so the chemical nature of the protein is changed. Proteins are specific for function, so if even one amino acid in a chain of thousands is incorrect, then yes..the protein can change its function (which is usually harmful to the organism or cell) or be rendered useless, which is also bad.
For example, people with hemophelia lack a particular enzyme (protein molecules that catalyze cellular chemical processes) in the clotting mechanism, so the blood takes a very, very long time to clot, if at all. This is because there is a gene on the DNA which is missing, so that particular enzyme protein molecule is not synthesized properly and affects the function of the entire enzyme chain responsible for proper blood clotting.
Proteins are made of chains of amino acids strung together, so if even one of them is incorrect, the structure of the protein is changed, along with its chemical function in the cell.
Wiki User
∙ 12y ago
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Most genetic disorders results from a mutation that changes the amino acid sequence in a?
Protein
A change in the sequence of DNA that results in a protein that is too short?
Nonsense mutation
What type of mutation results when nucleotide is dropped from a DNA sequence?
deletion
Mutation results from an extra nucleotide being added into the sequence?
this is called Insertion.
How can a point mutation alter the final structure of a protein?
In a point mutation, one nitrogen base is substituted for the correct base. Since most amino acids can be coded for by more than one codon, there may be no consequence to this mutation. However, sometimes a point mutation results in an incorrect amino acid being added to the amino acid sequence of the protein. This can cause a change in the shape and therefore function of the protein, which can be a harmful mutation. Two genetic disorders caused by a point mutation are cystic fibrosis and sickle cell anemia.
Most genetic disorders results from a mutation that changes the amino acid sequence in a?
Protein
A change in the sequence of DNA that results in a protein that is too short?
Nonsense mutation
What mutation stops translation of the mRNA?
The type of mutation that stops the translation of a protein is a nonsense mutation. This occurs when a base substitution (point mutation) results in a STOP codon and thus stops translation of the sequence into a protein.
What type of mutation could result in a much shorter protein than the original gene product?
the mutation can be a deletion one or even code for a stop, alternatly if can change the stop code and make a longer protein
Which type of mutation results in the formation of a protein with one incorrect amino acid-?
Missense is a type of mutation which results in the formation of a protein with one incorrect amino acid.
What type of mutation results when nucleotide is dropped from a DNA sequence?
deletion
Which type of mutation results in abnormal acid sequence?
A point mutation causes a change in the amino acid sequence creating a new type of protein. The mutations are categorized functionally as nonsense, missense and silent mutations.
What results in a regular size protein that is misshapen?
Missense mutation
Mutation results from an extra nucleotide being added into the sequence?
this is called Insertion.
How can a point mutation alter the final structure of a protein?
In a point mutation, one nitrogen base is substituted for the correct base. Since most amino acids can be coded for by more than one codon, there may be no consequence to this mutation. However, sometimes a point mutation results in an incorrect amino acid being added to the amino acid sequence of the protein. This can cause a change in the shape and therefore function of the protein, which can be a harmful mutation. Two genetic disorders caused by a point mutation are cystic fibrosis and sickle cell anemia.
When when a mutation results in no significant change in the production of a of a functional protein?
When a mutation does not change the result of a normal production of a protein is called harmless. This is because it does no harm to the individual.
Where could you make mistakes in recombining DNA and what would the results be?
Recombination is a processes that results in changes to a genome.A mutation is a change in the nucleotide sequence. A mutation in a key gene may cause the cell to die if the protein coded is defective.Recombination is a large scale rearrangement of the DNA molecule. It could happen through exchange of segments of homologous chromosomes during meiosis or by moving a segment from one position to another within a chromosome or between chromosomes.All events that are not deadly may to contribute to the evolution of the genome.Recombination is a processes that results in changes to a genome.A mutation is a change in the nucleotide sequence. A mutation in a key gene may cause the cell to die if the protein coded is defective.Recombination is a large scale rearrangement of the DNA molecule. It could happen through exchange of segments of homologous chromosomes during meiosis or by moving a segment from one position to another within a chromosome or between chromosomes.All events that are not deadly may to contribute to the evolution of the genome.
