Metaphase
The G phase of the cell cycle is most variable in length. It is also referred to as the G1 phase.
Simply: tumor cells tend to be more radiosensitive because they spend more time on average undergoing uncontrolled mitosis than normal cells. Since mitosis is the most sensitive phase of the cell cycle (phase through which the cell is most easily lethally damaged by radiation), their risk is increased. On another note, depending on which genes are causing the cell to become cancerous, certain blockers that would prevent a cell whose DNA had been damaged by radiation might not stop that cell from moving into mitosis, failing, and committing apoptosis (preprogrammed cell death).
Most cancerous tumors are detected at advanced phase of the cell cycle.
Interphase
Interphase is most frequently observed because it is the longest phase of the cell cycle.
Interphase is the metabolic or growth phase of a cell life cycle. The cell spend most of their life in this cycle preparing for cellular division.
G o phase
DNA replication
M phase (apex)
In the S-Phase, the most important part of cell cycle, the DNA (genome) replicates. It is then followed by division of the cell. If the s- phase fails to occur, a checkpoint before the division phase prevents the further proceedings of the cell cycle. Hence without the happening of S-phase, cell division will never complete.
Most anticancer drugs such as the antimetabolites. alkalating agents and platinum based drugs target the S-phase of the cell cycle ( DNA replication/synthesis phase) Other drugs like the antimicrotubules target the G2-M phase of the cell cycle
Interphase is the first and longest stage of the cell cycle.MORE: Interphase is made up of three distince phases (G1, S and G2 phase).The problem is that the cell cycle phases are actually all rather fluid; they overlap and can vary in length. In addition in some cases the cell does not need to undergo the full G1 or G2 phases such as in the early replication of zygotes.The actual longest phase of the cell cycle is what is called "G0". This is the state the cell goes into where it is not preparing for the cell cycle. Most of your cells are in G0 right now.