When acetylcholine binds to receptors at the motor plate, this binding opens ligand-gated ion channels on the motor end plate, ions diffuse through the open ligand gated ion channels, and the flow of ions causes the motor end plate to reach threshold and an action potential is generated at the motor end plate.
from answers.com When a nerve impulse reaches an axon ending, voltage-gated calcium channels in the axonal membrane open and calcium, which is extremely low inside the cell, enters the nerve ending. The increase in calcium-ion concentration causes hundreds of synaptic vesicles to fuse with the cell membrane and expel acetylcholine into the synaptic cleft (exocytosis). The acetylcholine released at a neuromuscular junction binds reversibly to acetylcholine receptors in the muscle end-plate membrane, a postsynaptic membrane that is separated from the nerve ending by a very short distance. The receptor is a cation channel which opens when two acetylcholine molecules are bound, allowing a sodium current to enter the muscle cell and depolarize the membrane. The resulting impulse indirectly causes the muscle to contract.
Alpha-Motor neurons release the neurotransmitter acetylcholine at a synapse called the neuromuscular junction. When the acetylcholine binds to acetylcholine receptors on the muscle fiber, an action potential is propagated along the muscle fiber in both directions.
The neurotransmitter acetylcholine is released into the synaptic cleft to bind with receptors on muscle cells. Upon binding, the muscle cells contract.
ACh (acetylcholine) binds to receptors at the NMJ (neuromuscular junction) to induce contraction of muscle.
A signal is generated in the motor cortex of the brain, and travels down the spinal cord to the affected motor neurons. As the action potential travels down the axon of the final motor neuron, it causes calcium influx and exocytosis of acetylcholine-containing vesicles, releasing acetylcholine into the neuromuscular junction. From there, acetylcholine binds with receptors on the muscle fiber end plates, where it depolarizes the muscle fiber, causing contraction of the muscle.
binding of acetylcholine to membrane receptors on the sarcolemma
Acetylcholine
Sarcolema receptors
from answers.com When a nerve impulse reaches an axon ending, voltage-gated calcium channels in the axonal membrane open and calcium, which is extremely low inside the cell, enters the nerve ending. The increase in calcium-ion concentration causes hundreds of synaptic vesicles to fuse with the cell membrane and expel acetylcholine into the synaptic cleft (exocytosis). The acetylcholine released at a neuromuscular junction binds reversibly to acetylcholine receptors in the muscle end-plate membrane, a postsynaptic membrane that is separated from the nerve ending by a very short distance. The receptor is a cation channel which opens when two acetylcholine molecules are bound, allowing a sodium current to enter the muscle cell and depolarize the membrane. The resulting impulse indirectly causes the muscle to contract.
Curare is a competitive inhibitor of acetylcholine. It fights with acetycholine for postsynaptic receptors.
When the Ach binds to receptor sites on the muscle cell membrane it causes channels to open and allows Na+ to move into the cell which then causes an action potential.
If the acetylcholine receptor was destroyed that the effector cells cannot respond or detect the neurotransmitter, resulting in muscle paralysis.
Alpha-Motor neurons release the neurotransmitter acetylcholine at a synapse called the neuromuscular junction. When the acetylcholine binds to acetylcholine receptors on the muscle fiber, an action potential is propagated along the muscle fiber in both directions.
The neurotransmitter acetylcholine is released into the synaptic cleft to bind with receptors on muscle cells. Upon binding, the muscle cells contract.
Acetylcholine (ACh) is the only neurotransmitter used in the motor division of the somatic nervous system. It works by binding to acetylcholine receptors on skeletal muscle fibers and opening ligand-gated sodium channels in the cell membrane.
Acetylcholine (ACh) is the only neurotransmitter used in the motor division of the somatic nervous system. It works by binding to acetylcholine receptors on skeletal muscle fibers and opening ligand-gated sodium channels in the cell membrane.
Alpha-Motor neurons release the neurotransmitter acetylcholine at a synapse called the neuromuscular junction. When the acetylcholine binds to acetylcholine receptors on the muscle fiber, an action potential is propagated along the muscle fiber in both directions.