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Orange Juice is Acidic - Alka-Seltzer is a base (Alkaline) - It would be like trying to light a candle made out of ice. What you can do is putt 60 Alka-Seltzer tablets in a glass mason jar with 80% water in it and screw that top on tightly to deal with depression and heartburn. I found this works better than mixing with orange juice. I also know how to make a hole in a beer can toward the top so essentially you are drinking out of a cup for increased guzzle ability.

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Q: What happens if you dissolve alka seltzer in orange juice and Will alka seltzer dissolve faster slower or the same as in water?
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You will get a chemical reaction. Alka Seltzer is alkaline and Kool Aid is acidic (citric acid). And acid and a base (alkaline) will always react chemically and form a new compound.