0
Tumor suppressor genes are normal genes that carry out several functions: * slow down cell division * repair mistakes made when DNA is being replicated * tell cells when to die (a process known as apoptosis or programmed cell death) A mutation in a tumor suppressor gene allows cells to grow out of control, which can lead to cancer ie the growth of a tumor. About 30 tumor suppressor genes have been identified, including p53, BRCA1, BRCA2, APC, and RB1. A good analogy for tumor suppressor genes is the brake pedal on a car - it normally keeps the cell from dividing too quickly just as a brake keeps a car from going too fast. If the brakes on a car fail, the car goes out of control; similarly, when something goes wrong with the gene, such as a mutation, cell division can get out of control. See: http://www.cancer.org/docroot/ETO/content/ETO_1_4x_oncogenes_and_tumor_suppressor_genes.asp http://envirocancer.cornell.edu/FactSheet/Genetics/fs6.TSgenes.cfm http://www.cancerquest.org/index.cfm?page=52
Wiki User
∙ 16y ago
Wiki User
∙ 14y agoTumor suppressor and oncogenes are two very important types of genes, deeply involved in cancer. First a tumor suppressor gene, is a gene, that helps to prevent cancer, by coding for the self-desturction of a cell, when the cells are damaged or something malfunctions, they destroy the cell. These genes also help to repress the cell cycle and help it from running awry. On the other hand an oncogene, is a mutated proto-oncogene, these proto-oncogenes, are responsible for controlling the cell cycle and when they mutate into oncogenes, they code for the cell to divide at a far accelerated pace, leading to a cancerous tumor.
Wiki User
∙ 10y agogene codeing for protein that supress cell division.
Wiki User
∙ 13y agoanti-oncogene
Add your answer:
Earn +20 pts
What is the difference between a tumor suppressor gene and an oncogene?
Oncogenes regulate cell division, so if it is placed near an overly active gene, it may itself become overly active, thus causing cancer. Tumor suppressors suppress tumors and will only cause cancer if it stops its activity, contrary to oncogenes.
What effect does oncogenes have on cells?
Cells with an oncogene become over-stimulated to divide more often than normal. The chances of cancer developing are increased if a mutation to a tumor-suppressor gene also occurs. As an oncogene is a cancer-causing gene
What two types of defects does a cancerous cell possess?
Cancerous cells possess defects that make proteins required for cell growth active and tumor suppressor genes inactive.
The genes that handle proteins necessary for cell division are?
C. proto-oncogenes
What are Stability Genes?
Stability genes are one of the three main genes, that when mutated are associated with cell progression towards tumorigenicity. It's normal function is to control the rate of mutation, but if mutated it off-balances, effecting oncogene and tumor suppressor function. In other words, accelerating the mutation process.
Why cancer is caused by multifactorial traits?
because it have two clases of genes involved: oncogenes and tumor suppressor genes
The loss of function of which allows cells to migrate from their home tissue to other areas?
a. plasma membrane adhesion proteins b. cell membranes c. cell walls d. oncogenes e. tumor suppressor genes
The two types of cell cycle genes if mutated cause cancer cells to divide uncontrollably are called tumor suppressor genes and?
The two types of cell cycle genes that cause cancer cells to divide uncontrollably if mutated are called tumor suppressor genes and antioncogene
Difference between proto-oncogenes and tumor suppressor genes?
During the division of the cell membrane (CYTOKINESIS), animal cells divide the cytoplasm by constricting the cell membrane in the middle to form a CLEAVAGE FURROW while plant cells form a CELL PLATE.
What are two types of genes that when disrupted can cause cancer?
The two genes considered responsible for the cause of cancer are the oncogene and the tumor suppressor gene.
Where can one find information about Tumor Suppressor Genese?
You can find information about Tumor Suppressor Genes in Bio Portfolio, Chips Books, Cancer Res, Academic Research Microsoft, Nature,Freezing Blue, Cancer 2000.
Explain how mutations in tumor suppressor genes can contribute to cancer?
Well, tumor suppressor genes are basically proteins that regulate the eradication of cells that develop mutations in the G1 or G2 phase of the cell cycle. For example, lets say a 54 year old patient has the Trp53 tumor suppressor protein mutation. What this means is that this patient has less of an ability to sense cells with mutations in the pancreas because they are deficient or void of the tumor suppressor protein, Trp53. Thus, this patient has an increased risk of pancreatic Adenocarcinoma, the most common form of pancreatic cancer.
What is the difference between a tumor suppressor gene and an oncogene?
Oncogenes regulate cell division, so if it is placed near an overly active gene, it may itself become overly active, thus causing cancer. Tumor suppressors suppress tumors and will only cause cancer if it stops its activity, contrary to oncogenes.
What is apc?
APC is classified as a tumor suppressor gene. Tumor suppressor genes prevent the uncontrolled growth of cells that may result in cancerous tumors. The protein made by the APC gene plays a critical role in several cellular processes that determine whether a cell may develop into a tumor.
What are three categories of genes that when mutated can lead to tumor formation?
· 1) Genes involved in cell division · 2) Oncogenes o Dominant-acting stimulatory genes o Normally low levels or expression is turned off o Mutation causes increased/hyper expression · 3) Tumour suppressor genes o Recessive-acting genes o Normally expressed to inhibit cell division o Mutation causes defects in product or no expression
What characteristic of cells determines how much they grow in size?
If this is concerning cancer, than oncogenes and tumor suppressor genes control the amount and rate of cell division, but probably not actual size. If I had to take a guess, I would say that the endoplasmic reticulum is responsible for membrane size, as it manufactures and distributes the supplies needed for creating and repairing the cell membrane.
Checkpoint genes that stimulate mitosis are called?
oncogenes
