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I guess you mean Roman Empire If so Rome and Milan. When Milan was the capital of the west, it surpassed Rome in importance because the imperial court was there. Christianity was made the state religion of the empire with the Edict of Milan. Two fathers of the Catholic church worked in Milan. St Ambrose was born in Milan and St Augustine (whose ideas became the foundation of the catholic doctrine) converted to Christianity after he moved to Milan and did his theological work there.

When the capital of the west was transferred to Ravenna, primacy over Catholic Christianity gradually went back to Rome.

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Q: What City in the West served as the center of Christianity in rome?
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