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There is a part of the brain called the hypothalamus which is next to the pituitary. When you have not enough Thyroxine (T4) your hypothalamus makes TRH which tells the pituitary to make Thyroid stimulating hormone (TSH).

TSH as in the name stimulates the thyroid gland in the neck to make more Thyroxine.

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Q: How does the body know when to produce more thyroxine?
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