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You can, but it would probably taste bad. (Hot mayo?)

As long as it's mayonnaise out of a jar, not home-made, you can put a sandwich with mayonnaise in it on a sandwich grill, or in a frying pan, and it's great.

Using a microwave, mayonnaise should be mixed, because otherwise its high fat content will cause it to heat before the other ingredients.

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Q: Can you cook a sandwich with mayonnaise on it?
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