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I was prescribed both methylprednisolone and vicodin by my doctor for a back injury. Therefore I'm assuming its safe (for me and my lack of pre-existing medical conditions at least) to take both. However, I wouldn't recommend it. The first day I took a 750mg vicodin on top of my methylprednisolone dosage, I was in bed for about 3 hours feeling like i was going to throw up. I personally tend to have that reaction to pain killers anyway though. NOT fun! I'd start with a half dose of vicodin first to see how you react.

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12y ago
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10y ago

Yes, generally. Doctors often prescribe steroids and narcotic pain medication together. Now if you have certain problems like kidney disease, special precautions would likely need to be taken.

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15y ago

May interact; Talk with your Doctor.

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12y ago

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Q: Can you take nsaids with methylprednisolone?
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