The Chicago Cubs beat the Detroit Tigers (1907 & 08). In
2016 the Cubs beat the Cleveland Indians.
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In interleague play through the 2012 season, the Cubs and
Indians are tied with 7 wins each.
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Ralph Kiner played 10 seasons in MLB: 1946-1952: Pittsburgh
Pirates
1953: Pittsburgh Pirates, Chicago Cubs
1954: Chicago Cubs
1955: Cleveland Indians
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Dave Clark.
Clark hit the first home run as a Cubs' DH on August 31, 1997
against the Cleveland Indians in the 8th inning of the Cubs 9-5
loss.
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Wayne Cage debuted on April 22, 1978, playing for the Cleveland
Indians at Cleveland Stadium; he played his final game on September
30, 1979, playing for the Cleveland Indians at Cleveland
Stadium.